Flavonoids from Scutellaria barbata inhibit activation of tumor-associated macrophages by blocking the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB signaling pathway.
Identifieur interne : 000248 ( Main/Exploration ); précédent : 000247; suivant : 000249Flavonoids from Scutellaria barbata inhibit activation of tumor-associated macrophages by blocking the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB signaling pathway.
Auteurs : Xiaoxia Bao [République populaire de Chine] ; Liuye Li [République populaire de Chine] ; Xiaoou Xue [République populaire de Chine]Source :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [ 2589-451X ] ; 2019.
Descripteurs français
- KwdFr :
- Facteur de différenciation myéloïde-88 (métabolisme), Facteur de transcription NF-kappa B (métabolisme), Flavonoïdes (pharmacologie), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Macrophages (cytologie), Macrophages (effets des médicaments et des substances chimiques), Macrophages (métabolisme), Prolifération cellulaire (effets des médicaments et des substances chimiques), Récepteur de type Toll-4 (métabolisme), Scutellaria (composition chimique), Transduction du signal (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Scutellaria.
- cytologie : Macrophages.
- effets des médicaments et des substances chimiques : Macrophages, Prolifération cellulaire, Transduction du signal.
- métabolisme : Facteur de différenciation myéloïde-88, Facteur de transcription NF-kappa B, Macrophages, Récepteur de type Toll-4.
- pharmacologie : Flavonoïdes.
- Humains, Lignée cellulaire tumorale.
English descriptors
- KwdEn :
- Cell Line, Tumor (MeSH), Cell Proliferation (drug effects), Flavonoids (pharmacology), Humans (MeSH), Macrophages (cytology), Macrophages (drug effects), Macrophages (metabolism), Myeloid Differentiation Factor 88 (metabolism), NF-kappa B (metabolism), Scutellaria (chemistry), Signal Transduction (drug effects), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , metabolism : Myeloid Differentiation Factor 88, NF-kappa B, Toll-Like Receptor 4.
- chemical , pharmacology : Flavonoids.
- chemistry : Scutellaria.
- cytology : Macrophages.
- drug effects : Cell Proliferation, Macrophages, Signal Transduction.
- metabolism : Macrophages.
- Cell Line, Tumor, Humans.
Abstract
OBJECTIVE
To determine the efficacy of Scutellaria barbata flavonoids and polysaccharides on Ishikawa endometrial carcinoma cells co-cultured with U937 macrophages.
METHODS
The presence of CD163 and CD206 was determined by flow cytometry. Thiazolyl Blue Tetrazolium Bromide assays were used to assess the proliferation effect of tumor-associated macrophages (TAMs) on Ishikawa cells. The secretion of interleukin (IL)-10 in the co-culture conditioned media was examined using an enzyme-linked immunosorbent assay. The protein expression levels of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and nuclear factor (NF)-κB p65 were detected by Western blot. The mRNA expression levels of TLR4 and MyD88 were analyzed by real-time polymerase chain reaction (PCR). The expression levels of IL-12, IL-1β and tumor necrosis factor-α (TNF-α) were evaluated with real-time PCR.
RESULTS
Compared with the U937 control group, the expression levels of CD163 and CD206 in the TAM group were higher (P < 0.05). TAMs co-cultured with Ishikawa cells for 24 or 48 h showed higher proliferation rates (P < 0.05). The expression levels of IL-12 decreased than compared with those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05). The expression levels of CD206, CD163, IL-10, IL-1β and TNF-α, NF-κB p65 and TLR4/MyD88 in the TAMs control group were greater than those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05).
CONCLUSION
Scutellaria barbata flavonoids may inhibit TAM activation by blocking the TLR4/MyD88/NF-κB signaling pathway.
PubMed: 32186037
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Li, Liuye" sort="Li, Liuye" uniqKey="Li L" first="Liuye" last="Li">Liuye Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<series><title level="j">Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line, Tumor (MeSH)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Flavonoids (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Macrophages (cytology)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (metabolism)</term>
<term>Myeloid Differentiation Factor 88 (metabolism)</term>
<term>NF-kappa B (metabolism)</term>
<term>Scutellaria (chemistry)</term>
<term>Signal Transduction (drug effects)</term>
<term>Toll-Like Receptor 4 (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Facteur de différenciation myéloïde-88 (métabolisme)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Flavonoïdes (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Macrophages (cytologie)</term>
<term>Macrophages (effets des médicaments et des substances chimiques)</term>
<term>Macrophages (métabolisme)</term>
<term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Récepteur de type Toll-4 (métabolisme)</term>
<term>Scutellaria (composition chimique)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Myeloid Differentiation Factor 88</term>
<term>NF-kappa B</term>
<term>Toll-Like Receptor 4</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavonoids</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Scutellaria</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Scutellaria</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
<term>Macrophages</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Macrophages</term>
<term>Prolifération cellulaire</term>
<term>Transduction du signal</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
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<term>Facteur de transcription NF-kappa B</term>
<term>Macrophages</term>
<term>Récepteur de type Toll-4</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Flavonoïdes</term>
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<keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To determine the efficacy of Scutellaria barbata flavonoids and polysaccharides on Ishikawa endometrial carcinoma cells co-cultured with U937 macrophages.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>The presence of CD163 and CD206 was determined by flow cytometry. Thiazolyl Blue Tetrazolium Bromide assays were used to assess the proliferation effect of tumor-associated macrophages (TAMs) on Ishikawa cells. The secretion of interleukin (IL)-10 in the co-culture conditioned media was examined using an enzyme-linked immunosorbent assay. The protein expression levels of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and nuclear factor (NF)-κB p65 were detected by Western blot. The mRNA expression levels of TLR4 and MyD88 were analyzed by real-time polymerase chain reaction (PCR). The expression levels of IL-12, IL-1β and tumor necrosis factor-α (TNF-α) were evaluated with real-time PCR.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Compared with the U937 control group, the expression levels of CD163 and CD206 in the TAM group were higher (P < 0.05). TAMs co-cultured with Ishikawa cells for 24 or 48 h showed higher proliferation rates (P < 0.05). The expression levels of IL-12 decreased than compared with those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05). The expression levels of CD206, CD163, IL-10, IL-1β and TNF-α, NF-κB p65 and TLR4/MyD88 in the TAMs control group were greater than those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Scutellaria barbata flavonoids may inhibit TAM activation by blocking the TLR4/MyD88/NF-κB signaling pathway.</p>
</div>
</front>
</TEI>
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<Abstract><AbstractText Label="OBJECTIVE">To determine the efficacy of Scutellaria barbata flavonoids and polysaccharides on Ishikawa endometrial carcinoma cells co-cultured with U937 macrophages.</AbstractText>
<AbstractText Label="METHODS">The presence of CD163 and CD206 was determined by flow cytometry. Thiazolyl Blue Tetrazolium Bromide assays were used to assess the proliferation effect of tumor-associated macrophages (TAMs) on Ishikawa cells. The secretion of interleukin (IL)-10 in the co-culture conditioned media was examined using an enzyme-linked immunosorbent assay. The protein expression levels of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and nuclear factor (NF)-κB p65 were detected by Western blot. The mRNA expression levels of TLR4 and MyD88 were analyzed by real-time polymerase chain reaction (PCR). The expression levels of IL-12, IL-1β and tumor necrosis factor-α (TNF-α) were evaluated with real-time PCR.</AbstractText>
<AbstractText Label="RESULTS">Compared with the U937 control group, the expression levels of CD163 and CD206 in the TAM group were higher (P < 0.05). TAMs co-cultured with Ishikawa cells for 24 or 48 h showed higher proliferation rates (P < 0.05). The expression levels of IL-12 decreased than compared with those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05). The expression levels of CD206, CD163, IL-10, IL-1β and TNF-α, NF-κB p65 and TLR4/MyD88 in the TAMs control group were greater than those in the U937 untreated group (P < 0.05) and those of the Scutellaria barbata flavonoids group (P < 0.05).</AbstractText>
<AbstractText Label="CONCLUSION">Scutellaria barbata flavonoids may inhibit TAM activation by blocking the TLR4/MyD88/NF-κB signaling pathway.</AbstractText>
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<Keyword MajorTopicYN="Y">Flavonoids</Keyword>
<Keyword MajorTopicYN="Y">Macrophages</Keyword>
<Keyword MajorTopicYN="Y">Myeloid differentiation factor 88</Keyword>
<Keyword MajorTopicYN="Y">Scutellaria baicalensis</Keyword>
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